metformin for the prevention of bladder cancer recurrence: is it effective?

Metformin for the Prevention of Bladder Cancer Recurrence: Is it Effective?

BACKGROUND Many methods have been used for preventing and reducing recurrences of bladder cancers. In recent years, some investigators have examined the use of metformin for this purpose. First lines of evidence have shown that metformin inhibits cancer cell growth and prevents cancer occurrence in patients with type 2 diabetes. OBJECTIVES This study is designed to assess metformin usage in t...

Metformin for cancer and aging prevention: is it a time to make the long story short?

During the last decade, the burst of interest is observed to antidiabetic biguanide metformin as candidate drug for cancer chemoprevention. The analysis of the available data have shown that the efficacy of cancer preventive effect of metformin (MF) and another biguanides, buformin (BF) and phenformin (PF), has been studied in relation to total tumor incidence and to 17 target organs, in 21 var...

Injury prevention training: is it effective.

The aim of this controlled follow-up study was to assess the effectiveness of a multi-disciplinary training programme in increasing knowledge, changing attitudes and practice in injury prevention amongst primary health care professionals. All primary health care team members in Nottinghamshire were invited to participate in the training programme. Thirty-one health visitors, 11 general practiti...

Screening for cancer: is it cost effective?

Screening is defined as the presumptive identification of unrecognized disease or defect by the application of tests, examinations, or other procedures that can be applied rapidly and carried out in the general population or in individuals at high risk. When considering immunochemical or biochemical cancer markers, it might be more appropriate to describe these tests as risk-factor monitors and...

6 Prevention of Bladder Tumor Recurrence

Innate inflammation and cancer: Is it time for cancer prevention?

Recently, studies have been reported indicating that daily aspirin treatment for a period of 5 years or longer has a significant protective effect against death by colorectal carcinoma (as has previously been shown) and also against death by other solid cancers, both gastrointestinal and otherwise. These studies have reignited interest in the possibility of using nonsteroidal anti-inflammatory ...